Zollinger-Ellison syndrome [Neurosurgery Wiki]

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====== Zollinger-Ellison syndrome ======

The incidence of pituitary tumors is increased in multiple endocrine adenomatosis or neoplasia
(MEA or MEN) (especially type I: autosomal dominant inheritance with high penetrance, also involves
pancreatic islet cell tumors (which may produce gastrin and hence Zollinger-Ellison syndrome) and
parathyroids (hyperparathyroidism), and in which the pituitary tumors are usually nonsecretory).
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[[Omeprazole]] for Zollinger-Ellison syndrome: 20mg PO q d to 120mg PO TID (dose adjusted to keep basal acid
output < 60 mEq/hr). Side effects: N/V, H/A, diarrhea, abdominal pain or rash in 1–5% of patients.
Supplied: 10, 20 & 40mg delayed-release capsules. Available OTC in 20.6mg tablets as Prilosec OTC.
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Zollinger-Ellison syndrome, can inhibit attachment of intrinsic factor to ileal receptors and so vitamin B12 deficiency.