Window of opportunity clinical trial [Neurosurgery Wiki]

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====== Window of opportunity clinical trial ======

Window of opportunity trials allow a drug (or other intervention) of interest to be given to a patient over a short period of time, usually 2–-4 weeks, prior to the instigation of standard therapy.


[[Window of opportunity clinical trial]] designs can provide early insight into the biological plausibility of a novel therapeutic [[strategy]] in the clinical setting. A variety of window-of-opportunity trial designs, which take into account the limited access to treated [[tissue]] and the challenges with obtaining pretreatment control tissues, have been used for the initial development of traditional and targeted small-molecule [[drug]]s and biologic therapies, including immunotherapies and oncolytic viral therapies. Early-stage development of [[glioma treatment]] should include a window-of-opportunity component whenever feasible
((Vogelbaum MA, Li G, Heimberger AB, Lang FF, Fueyo J, Gomez-Manzano C, Sanai N. A Window of Opportunity to Overcome Therapeutic Failure in Neuro-Oncology. Am Soc Clin Oncol Educ Book. 2022 Apr;42:1-8. doi: 10.1200/EDBK_349175. PMID: 35580289.)).