Urea [Neurosurgery Wiki]

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====== Urea ======



Urea or carbamide is an organic compoond wi the chemical formula CO(NH2)2. The molecule haes twa —NH2 groups jyned bi a carbonyl (C=O) functional group. Urea serves an important role in the metabolism o nitrogen-conteenin compoonds bi ainimals, an is the main nitrogen-containin substance in the urine o mammals.
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Despite widespread use of a number of [[osmolar]] agents ([[mannitol]], [[urea]], and [[glycerol]]) up until the late 1970s
((James HE, Langfitt TW, Kumar VS, et al: Treatment of intracranial
hypertension. Analysis of 105 consecutive, continuous recordings of
intracranial pressure. Acta Neurochir (Wien) 1977; 36:189–200))
((Pitlick WH, Pirikitakuhlr P, Painter MJ, et al: Effect of glycerol and
hyperosmolality on intracranial pressure. Clin Pharmacol Ther 1982;
31:466–471)),
mannitol gradually became the agent of choice to manage ICP
((James HE, Langfitt TW, Kumar VS, et al: Treatment of intracranial
hypertension. Analysis of 105 consecutive, continuous recordings of
intracranial pressure. Acta Neurochir (Wien) 1977; 36:189–200)).