Show pageBacklinksCite current pageExport to PDFBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. [[Ubiquitin conjugating enzyme]]s, also known as E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step in the [[ubiquitination]] reaction that targets a protein for degradation via the [[proteasome]]. The ubiquitination process covalently attaches [[ubiquitin]], a short protein of 76 amino acids, to a [[lysine]] residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell. see [[UBE2C]]. ubiquitin_conjugating_enzyme.txt Last modified: 2024/06/07 02:50by 127.0.0.1