Twisted blood vessel [Neurosurgery Wiki]

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====== Twisted blood vessel ======

Tortuous or twisted arteries and veins are commonly seen in humans and animals. While mild tortuosity is a common anomaly without clinical symptoms, severe tortuosity can lead to various serious symptoms. Clinical observations have linked tortuous arteries and veins to aging, atherosclerosis, hypertension, genetic defects and diabetes mellitus.

[[Glioblastoma Multiforme]] (GBM) is a highly invasive brain cancer, with prominent vascular involvement, characterized by twisted blood vessel 
((Burger PC, Scheithauer BW (2007) Tumors of the Central Nervous System:
AFIP Atlas of Tumor Pathology. Washington DC: American Registry of
Pathology Press, Series 4. pp. 65–66.))
and infiltration along external vessel walls
((Farin A, Suzuki SO, Weiker M, Goldman JE, Bruce JN, et al. (2006)
Transplanted glioma cells migrate and proliferate on host brain vasculature: a
dynamic analysis. Glia 53: 799–808.))
which makes it resistant to treatment.