Tumor volume [Neurosurgery Wiki]

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====== Tumor volume ======

Precise volumetric assessment of [[brain tumor]]s is relevant for treatment [[planning]] and [[monitoring]]. However, [[manual segmentation]]s are time-consuming and impeded by intra- and interrater variabilities.

see [[ABC/2]] formula.

The long-used geometric calculation formula is 1/2 (length × width × height). However, it yields only rough estimates and is particularly unreliable for irregularly shaped masses. 
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Robust [[methodology]] that allows objective, automated, and observer-independent measurements of brain tumor volume, especially after resection, is lacking.

The volumetric method had the strongest agreement with regard to radiological response (κ = 0.96) when compared with 2D (κ = 0.54) or 1D (κ = 0.46) methods
((Kanaly CW, Mehta AI, Ding D, Hoang JK, Kranz PG, Herndon JE 2nd, Coan A,
Crocker I, Waller AF, Friedman AH, Reardon DA, Sampson JH. A novel, reproducible,
and objective method for volumetric magnetic resonance imaging assessment of
enhancing glioblastoma. J Neurosurg. 2014 Sep;121(3):536-42. doi:
10.3171/2014.4.JNS121952. Epub 2014 Jul 18. PubMed PMID: 25036205.)).