Tuberculous spondylodiscitis [Neurosurgery Wiki]

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=====Tuberculous spondylodiscitis=====
Tuberculous spondylodiscitis TSD is a more suppurative disease with abscess formation requiring surgical intervention and with spinal complications. Erdem et al. propose that using a constellation of constitutional symptoms (fever, back pain and weight loss), pulmonary involvement, high inflammatory markers and radiological findings will help to differentiate between TSD and brucellar spondylodiscitis BSD at an early stage before microbiological results are available
((Erdem H, Elaldi N, Batirel A, Aliyu S, Sengoz G, Pehlivanoglu F, Ramosaco E,
Gulsun S, Tekin R, Mete B, Balkan II, Sevgi DY, Giannitsioti E, Fragou A, Kaya S,
Cetin B, Oktenoglu T, DoganCelik A, Karaca B, Horasan ES, Ulug M, Inan A, Kaya S,
Arslanalp E, Ates-Guler S, Willke A, Senol S, Inan D, Guclu E, Tuncer-Ertem G,
Meric-Koc M, Tasbakan M, Senbayrak S, Cicek-Senturk G, Sırmatel F, Ocal G,
Kocagoz S, Kusoglu H, Guven T, Baran AI, Dede B, Yilmaz-Karadag F, Kose S, Yilmaz
H, Aslan G, ALGallad DA, Cesur S, El-Sokkary R, Bekiroğlu N, Vahaboglu H.
Comparison of brucellar and tuberculous spondylodiscitis patients: results of the
multicenter "Backbone-1 study". Spine J. 2015 Sep 16. pii: S1529-9430(15)01400-X.
doi: 10.1016/j.spinee.2015.09.024. [Epub ahead of print] PubMed PMID: 26386176.)).
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In most cases of [[tuberculous spondylodiscitis]], the treatment is medical with appropriate antibiotic therapy even in cases of abscess
((Moon MS. Development in the management of tuberculosis of the spine. Curr Orthop. 2006;20(2):132–140. doi: 10.1016/j.cuor.2005.12.002.)).
If the patient has neurological deficit, an abscess that did not resolve with antibiotics, and spinal instability
((Benli IT, Acaroğlu E, Akalin S, Kiş M, Duman E, Un A. Anterior radical debridement and anterior instrumentation in tuberculosis spondylitis. Eur Spine J. 2003 Apr;12(2):224-34. doi: 10.1007/s00586-002-0403-0. Epub 2002 Sep 13. PMID: 12709862; PMCID: PMC3784847.))
((Kumar R. Spinal tuberculosis: with reference to the children of northern India. Childs Nerv Syst. 2005 Jan;21(1):19-26. doi: 10.1007/s00381-004-1029-9. Epub 2004 Sep 30. PMID: 15459785.))
, open surgery is recommended