Tripartite motif 47 [Neurosurgery Wiki]

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====== Tripartite motif 47 ======
 
[[Angiogenesis]] is required for [[tumor progression]]; thus, its investigation can be useful to identify strategies for potential [[cancer treatment]]s. [[Tripartite motif 47]] (TRIM47) is involved in the progression of multiple [[cancer]]s. However, its role in [[glioma angiogenesis]] is largely unknown.

Wang et al. first showed that [[TRIM47]] is frequently upregulated in [[glioma]]s, and increased TRIM47 levels are correlated with microvascular density. They then examined the role of TRIM47 in cellular functions related to [[angiogenesis]] [[in vitro]] and observed that TRIM47 [[knockdown]] significantly reduced human [[umbilical vein]] [[endothelial cell]] [[proliferation]], [[migration]], and tube formation. They also found that TRIM47 silencing reduced vessel density and [[tumor volume]] in glioma [[xenograft]]s. Mechanistically, TRIM47 negatively regulated [[Smad4]] expression in [[glioma cell]]s, and SMAD4 knockdown rescued the suppressive effects of TRIM47 silencing. Taken together, the results indicate that TRIM47 promotes [[angiogenesis]] in gliomas by downregulating SMAD4. Therefore, targeting the TRIM47/SMAD4 axis may offer an innovative approach to [[glioma treatment]]
((Wang Z, Li Z, Han C, Cheng Y, Wang K. [[TRIM47]] promotes [[glioma angiogenesis]] by suppressing [[Smad4]]. In Vitro Cell Dev Biol Anim. 2022 Oct 6. doi: 10.1007/s11626-022-00722-6. Epub ahead of print. PMID: 36203070.)).