Traumatic brain injury clinical trials [Neurosurgery Wiki]

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====== Traumatic brain injury clinical trials ======

Although [[Traumatic brain injury]] is a leading cause of death and disability, none of the [[clinical trial]]s performed on these patients have shown an overall significant treatment effect. Many authors have published [[recommendation]]s in order to improve the statistical analysis and design of these [[trial]]s, such as an adequate prognostic model and the use of ordinal rather than dichotomous [[outcome analysis]] 
((Roozenbeek B, Lingsma HF, Perel P, Edwards P, Roberts I, Murray GD, Maas AI,
Steyerberg EW; IMPACT (International Mission on Prognosis and Clinical Trial
Design in Traumatic Brain Injury) Study Group; CRASH (Corticosteroid
Randomisation After Significant Head Injury) Trial Collaborators. The added value
of ordinal analysis in clinical trials: an example in traumatic brain injury.
Crit Care. 2011;15(3):R127. doi: 10.1186/cc10240. Epub 2011 May 17. PubMed PMID: 
21586148; PubMed Central PMCID: PMC3218993.
)).

Deep Brain Stimulation for Traumatic Brain Injury-https://clinicaltrials.gov/ct2/show/NCT01277952

Evaluation and Diagnosis of Potential Research Subjects With Traumatic Brain Injury- https://clinicaltrials.gov/ct2/show/NCT01287156