Translational neuro-oncology research [Neurosurgery Wiki]

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====== Translational neuro-oncology research ======

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**[[Translational]] [[Neuro-Oncology]] [[Research]]** refers to the process of applying discoveries from basic [[neuroscience]] and [[oncology]] research to clinical applications for brain and spinal cord tumors. It bridges the gap between [[laboratory]] findings and [[patient care]] by developing new diagnostic [[tool]]s, treatment strategies, and personalized therapies.

===== Key Areas =====

==== Molecular and Genetic Profiling ====

Identifying [[genetic mutation]]s and [[molecular pathway]]s involved in gliomas, medulloblastomas, and other CNS tumors.  

[[Next-generation sequencing]] (NGS) and [[liquid biopsy]] are used for tumor characterization.  

==== Targeted Therapies and Immunotherapy ====
  
Development of small-molecule inhibitors targeting pathways like EGFR, IDH1, and BRAF mutations.  

Advances in CAR-T cell therapy and checkpoint inhibitors for glioblastoma and other aggressive brain tumors.  

==== Tumor Microenvironment and Drug Resistance  ====
 
Understanding the blood-brain barrier (BBB) and strategies to enhance drug delivery (e.g., focused ultrasound, nanoparticles).  

Studying the role of hypoxia, immune suppression, and glioma stem cells in tumor progression.  

==== Advanced Imaging and Biomarkers  ====
 
Integration of MRI spectroscopy, PET imaging, and AI-driven radiomics for tumor detection and monitoring.  

Identification of biomarkers for early diagnosis and treatment response.  

==== Preclinical Models and Clinical Trials  ====
 
Use of patient-derived xenografts (PDX) and organoids to test new drugs.  

Adaptive trial designs for rapid assessment of novel therapies.  
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