tissue_adhesive [Neurosurgery Wiki]

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Existing tissue [[adhesive]]s and [[sealant]]s are far from satisfactory when applied on wet and dynamic tissues. 

Li et al. reported a strategy for designing biodegradable super-strong aqueous glue (B-Seal) for surgical uses inspired by an English ivy adhesion strategy and a cement particle packing theory. B-Seal is a fast-gelling, super-strong, and elastic adhesive sealant composed of injectable water-borne biodegradable [[polyurethane]] (WPU) nanodispersions with mismatched particle sizes and counterions in its A-B formulation. B-Seal showed 24-fold greater burst pressure than [[DuraSeal]]®, 138-fold greater T-pull adhesive strength than [[fibrin glue]], and 16-fold greater lap shear strength than fibrin glue. In vivo evaluation on a rat cerebrospinal fluid (CSF) rhinorrhea model and a porcine craniotomy model validated the safety and efficacy of B-Seal for effective Cerebrospinal fluid fistula prevention and dura repair. The plant-inspired adhesion strategy combined with particle packing theory represents a new direction of designing the next-generation wet tissue adhesives for surgeries
((Li Q, Song W, Li J, Ma C, Zhao X, Jiao J, Mrowczynski O, Webb BS, Rizk EB, Lu D, Liu C. Bioinspired Super-Strong Aqueous Synthetic Tissue Adhesives. Matter. 2022 Mar 2;5(3):933-956. doi: 10.1016/j.matt.2021.12.018. Epub 2022 Jan 25. PMID: 35252844; PMCID: PMC8896806.)).
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Shah AR, Pearlman AN, O'Grady KM, Bhattacharyya TK, Toriumi DM. Combined
use of fibrin [[tissue adhesive]] and acellular dermis in dural repair. Am J Rhinol.
2007 Sep-Oct;21(5):619-21. doi: 10.2500/ajr.2007.21.3078. PMID: 17999801.