Show pageBacklinksCite current pageExport to PDFFold/unfold allBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. Tipifarnib FGF-2 has been reported to controls radioresistance through RhoB, whose farnesylated form modulates radioresistance in GBM. Ducassou et al. treated 27 patients of newly diagnosed GBM with tipifarnib in continuous administration with RT starting 1 week before the initiation of radiation and TMZ was delivered at progression. Median OS was 80.3 weeks and median time to progression was 18.1 weeks. The study found FGF receptor-1 over-expression and avb3 as a negative prognostic factor ((Mallick S, Gandhi AK, Rath GK. Therapeutic approach beyond conventional temozolomide for newly diagnosed glioblastoma: Review of the present evidence and future direction. Indian J Med Paediatr Oncol. 2015 Oct-Dec;36(4):229-37. doi: 10.4103/0971-5851.171543. Review. PubMed PMID: 26811592; PubMed Central PMCID: PMC4711221. )). tipifarnib.txt Last modified: 2025/04/29 20:27by 127.0.0.1