Show pageBacklinksCite current pageExport to PDFBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. ====== Dysembryoplastic Neuroepithelial Tumor (DNET) - Temporal Lobe ====== ===== Overview ===== **Dysembryoplastic Neuroepithelial Tumor (DNET)** is a benign, WHO grade I glioneuronal tumor typically presenting in children and young adults with **long-standing, pharmacoresistant epilepsy**. The **temporal lobe** is the most common location. ===== Epidemiology ===== * Age: Childhood to young adulthood (most < 20 years) * Slight male predominance * ~80% of cases involve the **temporal lobe** ===== Clinical Presentation ===== * Chronic, intractable **focal epilepsy** * Often normal neurological exam * Rarely causes increased intracranial pressure or neurological deficits ===== Diagnosis ===== [[Dysembryoplastic Neuroepithelial Tumor Diagnosis]]. ===== Treatment ===== * **Surgical resection** is the treatment of choice * **Gross total resection** often cures epilepsy * Recurrence is rare ===== Prognosis ===== * Excellent long-term prognosis * Very low risk of malignant transformation * Seizure freedom in >80% after complete resection ===== Differential Diagnosis ===== * Ganglioglioma * Oligodendroglioma (especially low-grade) * Cortical dysplasia without tumor * Low-grade astrocytoma ===== References ===== * WHO Classification of Tumors of the CNS, 2021 * Guerrini R, et al. Epilepsy surgery and DNETs. Epilepsia. 2012. * Blumcke I, et al. Histopathological findings in long-term epilepsy surgery. Brain Pathol. 2007. temporal_lobe_dysembryoplastic_neuroepithelial_tumor.txt Last modified: 2025/07/11 06:40by administrador