Tau protein [Neurosurgery Wiki]

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====== Tau protein ======

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[[Tau]] [[protein]]s (or τ proteins, after the Greek letter by that name) are [[protein]]s that stabilize [[microtubule]]s. They are abundant in [[neuron]]s of the [[central nervous system]] and are less common elsewhere, but are also expressed at very low levels in CNS [[astrocyte]]s and [[oligodendrocyte]]s.

The tau proteins are the product of alternative splicing from a single gene that in humans is designated MAPT (microtubule-associated protein tau) and is located on [[chromosome 17]].

They were discovered in [[1975]] in Marc Kirschner's laboratory at Princeton University.

Pathologies and [[dementia]]s of the nervous system such as [[Alzheimer disease]] can result when tau proteins become defective and no longer stabilize microtubules properly.

see [[Tauopathy]].

===== Biomarker =====

[[Tau Biomarker]]