SURF4 [Neurosurgery Wiki]

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====== SURF4 ======

Surfeit locus [[protein]] 4 (SURF4) [[function]]s as a cargo receptor that is capable of [[transport]]ing newly formed [[protein]]s from the lumen of the [[endoplasmic reticulum]] into [[vesicle]]s and [[Golgi apparatus]]. However, the role of SURF4 in the [[central nervous system]] remains unclear.
Hu et al. investigated the role of SURF4 and its underlying mechanisms in [[cerebral ischemia-reperfusion injury]] in rats, and whether it can be used effectively for novel therapeutic intervention. They also examined whether [[transcranial direct current stimulation]] (tDCS) can exert a neuroprotective effect via SURF4-dependent signaling. Following cerebral I/R injury in rats, a significant increase was observed in the expression of SURF4. In both I/R injury and oxygen-glucose deprivation (OGD) insult, suppressing the expression of SURF4 demonstrated a neuroprotective effect, while overexpression of SURF4 resulted in increased neuronal death. They further showed that the levels of [[nerve growth factor precursor]] (proNGF), p75 neurotrophin receptor (p75NTR), [[sortilin]], and [[PTEN]] were increased following cerebral I/R injury and that SURF4 acted through the PTEN/proNGF signal pathway to regulate neuronal viability. They demonstrated that tDCS treatment reduced SURF4 expression and decreased the infarct volume after cerebral I/R injury. Together, this study indicates that SURF4 plays a critical role in ischemic [[neuronal injury]] and may serve as a [[molecular target]] for the development of therapeutic strategies in [[acute ischemic stroke]]
((Hu W, Kong X, Cui Y, Wang H, Gao J, Wang X, Chen S, Li X, Li S, Che F, Wan Q. Surfeit Locus Protein 4 as a Novel Target for Therapeutic Intervention in Cerebral Ischemia-Reperfusion Injury. Mol Neurobiol. 2023 Oct 16. doi: 10.1007/s12035-023-03687-z. Epub ahead of print. PMID: 37843800.))