Spondyloarthropathy [Neurosurgery Wiki]

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====== Spondyloarthropathy ======

They include [[ankylosing spondylitis]], reactive [[arthritis]], psoriatic arthritis, and joint problems linked to inflammatory bowel disease (enteropathic arthritis).
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Destructive spondyloarthropathy is a recently recognized disease that has not been reported in the neurosurgical literature. It is associated with spinal [[amyloid]] deposition in long-term [[renal failure]] and [[dialysis]], and it occurs increasingly as the number of dialysis patients and their survival times increase. Clinically, there is a multisegmental and often rapidly progressive [[radiculomyelopathy]] that may require emergency [[stabilization]]. The radiological features are [[disc space]] narrowing with erosion of vertebral [[end plate]]s and subarticular cysts. The pathological features include deposition of amyloid, which stains with Congo Red and antibodies to beta-2-microglobulin. 

Present two cases with clinical, radiological, and pathological features and a review of the literature
((Davidson GS, Montanera WJ, Fleming JF, Gentili F. Amyloid destructive spondyloarthropathy causing cord compression: related to chronic renal failure and dialysis. Neurosurgery. 1993 Sep;33(3):519-22. doi: 10.1227/00006123-199309000-00026. PMID: 8413887.))