2015 [Neurosurgery Wiki]

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Marques et al. report a five-generation kindred with two brothers with pituitary [[gigantism]] due to [[AIP]] [[mutation]]-positive [[GH secreting pituitary neuroendocrine tumor]]s and their first-cousin coincidently also having gigantism due to [[Marfan syndrome]] 
((Marques P, Collier D, Barkan A, Korbonits M. Coexisting pituitary and
non-pituitary gigantism in the same family. Clin Endocrinol (Oxf). 2018 Sep 17.
doi: 10.1111/cen.13852. [Epub ahead of print] PubMed PMID: 30223298.
)).
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===2015===
A 37-year-old woman has presented with complaints of [[headache]], [[amenorrhea]] and [[acromegaly]].

Her laboratory studies showed markedly elevated levels of [[Insulin like Growth Factor]] 1 (IGF-1), and low levels of [[follicle-stimulating hormone]] and luteinizing hormone. Computerized tomography has revealed a [[pituitary tumor]] without extra-sellar extension. The tumor has completely excised via [[Endoscopic transsphenoidal approach]]. Histologically, the tumor has diagnosed as a pituitary neuroendocrine tumor with [[GH]] positive cells. The serum IGF1 levels have gradually decreased to the normal range and the patient was symptom free for three and a half years when she has returned with complaint of visual impairment. The brain MRI that time has shown a supra-sellar mass growing independently into the remaining sellar part. Subsequently, surgical operation has performed via trans-nasal endoscopic approach. Histopathological and immunohistochemistry examination have revealed a rare case of growth hormone producing pituitary neuroendocrine tumor with brain invasion and lymphocytic infiltration.

The aim of this publication was to present a rare case of growth hormone producing pituitary neuroendocrine tumor with brain invasion and lymphocytic infiltration
((Bidari-Zerehpoosh F, Sharifi G, Novin K, Mortazavi N. Invasive Growth Hormone 
Producing pituitary neuroendocrine tumor With Lymphocytic Infiltration: A Case Report and
Literature Review. Iran J Cancer Prev. 2015 Dec;8(6):e3504. Epub 2015 Dec 23.
PubMed PMID: 26855718.
)).