SIK1 [Neurosurgery Wiki]

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====== SIK1 ======
Salt-Inducible [[Kinase]] 1 (SIK1).

[[SIK1]] is crucial to regulating [[alcohol]]-induced [[microglia]]l [[apoptosis]], but also that the [[NF-κB signaling pathway]] is required for its activity. Overall, the results of Zhang et al., help elucidate mechanisms of [[alcohol induced neuroinflammation]]
((Zhang Y, Gao W, Yang K, Tao H, Yang H. Salt-Inducible Kinase 1 (SIK1) is
Induced by Alcohol and Suppresses Microglia Inflammation via NF-κB Signaling.
Cell Physiol Biochem. 2018 Jun 19;47(4):1411-1421. doi: 10.1159/000490831. [Epub 
ahead of print] PubMed PMID: 29929190.
)).

This gene encodes a serine/threonine protein kinase that contains a ubiquitin-associated (UBA) domain. The encoded protein is a member of the adenosine monophosphate-activated kinase (AMPK) subfamily of kinases that play a role in conserved signal transduction pathways. A mutation in this gene is associated with early infantile epileptic encephalopathy ((provided by RefSeq, Nov 2016)).

[[SIK1]] is verified as the direct target of [[miR 489]] and it is negatively regulated by miR-489. [[ENST01108]] also positively regulate SIKI and it promotes SIKI expression by suppressing miR-489. Taken together, the reciprocal repression of ENST011081 and miR-489 may be served as potential targets for cancer therapeutics in glioma
((Xu D, Liu R, Meng L, Zhang Y, Lu G, Ma P. Long non-coding RNA ENST01108
promotes carcinogenesis of glioma by acting as a molecular sponge to modulate
miR-489. Biomed Pharmacother. 2018 Feb 5;100:20-28. doi:
10.1016/j.biopha.2018.01.126. [Epub ahead of print] PubMed PMID: 29421578.
)).