Restless legs syndrome treatment [Neurosurgery Wiki]

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====== Restless legs syndrome treatment ======

Its recognition and treatment are essential. However, [[screening]] methods present [[limitation]]s and should be improved. Moreover, available RLS treatment options albeit providing sustained relief to many patients are limited in number. Additionally, the development of [[augmentation]] with [[dopamine agonist]]s represents a major treatment problem. A better understanding of RLS [[pathomechanism]]s can bring to light novel treatment possibilities. With emerging new avenues of research in [[pharmacology]], [[imaging]], genetics, and [[animal model]]s of RLS, this is an interesting and constantly growing field of research
((Khachatryan SG, Ferri R, Fulda S, Garcia-Borreguero D, Manconi M, Muntean ML, Stefani A. Restless legs syndrome: Over 50 years of European contribution. J Sleep Res. 2022 Jul 9:e13632. doi: 10.1111/jsr.13632. Epub ahead of print. PMID: 35808955.)).

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The magnitude of the placebo response in RLS is above the threshold of [[Minimal clinically important difference]], and the frequency of [[adverse event]]s is also considerable. These results are relevant to inform the design and interpretation of future clinical trials
((Silva MA, Duarte GS, Camara R, Rodrigues FB, Fernandes RM, Abreu D, Mestre T, 
Costa J, Trenkwalder C, Ferreira JJ. Placebo and nocebo responses in restless
legs syndrome: A systematic review and meta-analysis. Neurology. 2017 Jun
6;88(23):2216-2224. doi: 10.1212/WNL.0000000000004004. Epub 2017 May 10. Review. 
PubMed PMID: 28490647.
)).

In patients who responded to treatment, ferric carboxymaltose may require more time to stabilize restless legs syndrome than previously assumed
((Trenkwalder C, Winkelmann J, Oertel W, Virgin G, Roubert B, Mezzacasa A;
FCM-RLS Study Investigators. Ferric carboxymaltose in patients with restless legs
syndrome and nonanemic iron deficiency: A randomized trial. Mov Disord. 2017 Jun 
23. doi: 10.1002/mds.27040. [Epub ahead of print] PubMed PMID: 28643901.
)).

see [[Intrathecal morphine for Restless Legs Syndrome]]

see [[Spinal Cord Stimulation for Restless Legs Syndrome]]