rela_gene [Neurosurgery Wiki]

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The [[RELA]] gene, also known as [[Nuclear Factor Kappa B subunit 3]] ([[NFKB3]]), is a gene that is involved in the regulation of a variety of cellular processes, including [[inflammation]], [[immune response]]s, and [[cell survival]]. The RELA gene is located on [[chromosome 11]] and encodes a protein called [[p65]], which is a subunit of the [[transcription factor]] [[NF-κB]].

NF-κB is a key regulator of the immune response and is activated in response to various stimuli, including infection, inflammation, and cellular stress. When activated, NF-κB translocates to the nucleus and binds to specific DNA sequences, regulating the expression of a wide range of genes involved in the immune response, cell proliferation, and apoptosis.

Mutations or dysregulation of the RELA gene have been associated with a variety of diseases, including [[cancer]], autoimmune disorders, and inflammatory diseases. In some cancers, such as lymphoma and multiple myeloma, the RELA gene is overexpressed, leading to increased NF-κB activity and tumor cell survival. Conversely, in some autoimmune and inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease, the RELA gene is downregulated, leading to decreased NF-κB activity and impaired immune responses.