RELA [Neurosurgery Wiki]

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====== RELA ======
[[Transcription factor]] [[p65]] also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the [[RELA gene]].

RELA, also known as [[p65]], is a REL-associated protein involved in [[NF-κB]] heterodimer formation, nuclear translocation and activation. NF-κB is an essential transcription factor complex involved in all types of cellular processes, including cellular metabolism, chemotaxis, etc. [[Phosphorylation]] and [[acetylation]] of RELA are crucial post-translational modifications required for NF-κB activation. RELA has also been shown to modulate immune responses, and activation of RELA is positively associated with multiple types of cancer.

The principal effector of canonical [[NF-κB]] signalling

===== RELA fusion =====

[[RELA fusion]]

===== Ependymoma RELA fusion positive =====

see [[Ependymoma RELA fusion positive]]