Rac1 [Neurosurgery Wiki]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
====== Rac1 ======

Rac1 is a small (~21 kDa) signaling [[G protein]] (more specifically a [[GTPase]]) and is a member of the [[Rac]] subfamily of the family [[Rho]] family of GTPases. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of [[GLUT4]] translocation to glucose uptake, [[cell growth]], cytoskeletal [[reorganization]], antimicrobial cytotoxicity, and the activation of protein kinases.

Rac1 is a pleiotropic regulator of many cellular processes, including the [[cell cycle]], cell-cell adhesion, motility (through the actin network), and epithelial differentiation (proposed to be necessary for maintaining epidermal stem cells).
----
Zhang et al crucially identified that [[KIF4A]] drives [[glioma]] [[growth]] by [[Rac1]]/[[Cdc42]] [[transcriptional repressor]]s to induce [[cytoskeletal remodeling]] in [[glioma cell]]s. [[Knockdown]] of KIF4A decreased [[RohA]], [[Rac1]], [[Cdc42]], [[Pak1]] and [[Pak2]] expression level. The study provided a prospect that KIF4A functions as an [[oncogene]] in glioma
((Zhang H, Meng S, Chu K, Chu S, Fan YC, Bai J, Yu ZQ. KIF4A drives glioma growth by transcriptional repression of Rac1/Cdc42 to induce cytoskeletal remodeling in glioma cells. J Cancer. 2022 Nov 21;13(15):3640-3651. doi: 10.7150/jca.77238. PMID: 36606197; PMCID: PMC9809311.)).