Show pageBacklinksCite current pageExport to PDFBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. ====== 💊 Prodrug ====== A prodrug is a pharmacologically inactive or less active compound that is converted into an active drug inside the body through metabolic or environmental processes (e.g., enzymatic activation, pH change, hypoxia). 📚 Formal Definition: A prodrug is a chemical compound that, after administration, undergoes biotransformation in vivo to release the pharmacologically active parent drug, improving aspects such as selectivity, solubility, bioavailability, or tissue targeting. ⚙️ Why use a prodrug? To reduce systemic toxicity To target specific tissues (e.g., hypoxic tumors, CNS) To improve absorption, distribution, metabolism, and excretion (ADME) profiles To bypass physiological barriers, such as the blood–brain barrier (BBB) prodrug.txt Last modified: 2025/06/21 17:31by administrador