Show pageBacklinksCite current pageExport to PDFBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. ====== Pro-inflammatory Oncogenic Driver ====== **Definition:** A *pro-inflammatory oncogenic driver* is a genetic or molecular alteration that simultaneously promotes **malignant transformation** (oncogenesis) and **chronic inflammation**, fostering tumor development and progression. ===== Key Features ===== * Activates inflammatory signaling pathways (e.g., NF-κB, STAT3). * Promotes cell proliferation, survival, and immune evasion. * Shapes the tumor microenvironment to support angiogenesis and metastasis. * Creates a positive feedback loop between inflammation and tumor growth. ===== Common Examples ===== ^ Driver / Pathway ^ Role in Inflammation and Cancer ^ | **Mutated KRAS** | Activates MAPK and NF-κB → increases pro-inflammatory cytokines. | | **MYC overexpression** | Regulates inflammatory and metabolic genes in the tumor environment. | | **Constitutive NF-κB** | Drives chronic inflammation and survival gene expression. | | **Activated STAT3** | Induces IL-6, VEGF, and other oncogenic inflammatory mediators. | | **TP53 loss** | Impairs immune surveillance → unresolved inflammation. | | **COX-2 overexpression** | Elevates prostaglandins → enhances inflammation and tumor growth. | ===== Clinical Relevance ===== * **Therapeutic Targeting:** These drivers are candidates for combined oncologic and anti-inflammatory therapies. * **Biomarkers:** Their dual role makes them valuable prognostic or predictive biomarkers. * **Immunotherapy Modulation:** Targeting these pathways may enhance immune responses against tumors. ===== References ===== * Greten, F.R., Grivennikov, S.I. (2019). Inflammation and Cancer: Triggers, Mechanisms, and Consequences. *Immunity*. * Mantovani, A., et al. (2008). Cancer-related inflammation. *Nature*. pro-inflammatory_oncogenic_driver.txt Last modified: 2025/06/30 23:03by administrador