Post-cardiac arrest syndrome [Neurosurgery Wiki]

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====== Post-cardiac arrest syndrome ======

[[Sudden cardiac arrest]] (SCA) is one of the leading causes of mortality and morbidity in the United States, and survivors are frequently left with severe disability. Of the 10% successfully resuscitated from SCA, only around 10% of these live with a favorable neurologic outcome. Survivors of SCA commonly develop [[post-cardiac arrest syndrome]] (PCAS). PCAS is composed of neurologic, myocardial, and systemic injury related to inadequate perfusion and ischemia-reperfusion injury with free radical formation and an inflammatory cascade. While [[targeted temperature management]] is the cornerstone of therapy, other [[intensive care unit]]-based management strategies include [[monitoring]] and treatment of [[seizure]]s, [[cerebral edema]], and increased [[intracranial pressure]], as well as prevention of further neurologic injury
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