Platelet-to-lymphocyte ratio for mechanical thrombectomy outcome [Neurosurgery Wiki]

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====== Platelet-to-lymphocyte ratio for mechanical thrombectomy outcome ======

The association with hemorrhagic change and the recovery parameters at the 24th hour may enable  [[platelet-to-lymphocyte ratio]] (PLR) and [[Neutrophil to lymphocyte ratio]] to be used as significant prognostic factors in patients with [[acute ischemic stroke]] undergoing [[mechanical thrombectomy]]. Further studies are needed
((Inanc Y, Inanc Y. The effects of neutrophil to lymphocyte and platelet to lymphocyte ratios on prognosis in patients undergoing mechanical thrombectomy for acute ischemic stroke. Ann Ital Chir. 2018;89:367-373. PMID: 30569899.)).
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The platelet-to-lymphocyte ratio could represent pro-thrombotic inflammatory state in acute ischemic stroke patients because having a high-PLR values increased the poor prognosis, the rate of insufficient recanalization, and the size of infarcted area
((Altintas O, Altintas MO, Tasal A, Kucukdagli OT, Asil T. The relationship of platelet-to-lymphocyte ratio with clinical outcome and final infarct core in acute ischemic stroke patients who have undergone endovascular therapy. Neurol Res. 2016 Sep;38(9):759-65. doi: 10.1080/01616412.2016.1215030. Epub 2016 Jul 30. PMID: 27477691.)).

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For Lee et al. Higher NLR and PLR were associated with unsuccessful reperfusion after EVT. The combined application of both biomarkers could be useful for predicting outcomes after EVT
((Lee SH, Jang MU, Kim Y, Park SY, Kim C, Kim YJ, Sohn JH. The Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios Predict Reperfusion and Prognosis after Endovascular Treatment of Acute Ischemic Stroke. J Pers Med. 2021 Jul 22;11(8):696. doi: 10.3390/jpm11080696. PMID: 34442341; PMCID: PMC8399654.)).
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A study demonstrated that both NLR and PLR were independent predictors of 3-months functional outcomes of AIS. They may help to identify high-risk patients more forcefully when combined together
((Chen C, Gu L, Chen L, Hu W, Feng X, Qiu F, Fan Z, Chen Q, Qiu J, Shao B. Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Potential Predictors of Prognosis in Acute Ischemic Stroke. Front Neurol. 2021 Jan 25;11:525621. doi: 10.3389/fneur.2020.525621. PMID: 33569032; PMCID: PMC7868420.)).
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In patients with  [[mechanical thrombectomy]] (MT), [[platelet-to-lymphocyte ratio]] (PLR) and [[Neutrophil to lymphocyte ratio]] on [[admission]] could be predictive factors of prognosis and mortality at 3 months. Decreased PLR and increased [[Neutrophil to lymphocyte ratio]] were associated with favorable clinical outcome 3 months after MT
((Kim SY, Yi HJ, Shin DS, Kim BT. Prognostic significance of platelet-to-lymphocyte and platelet-to-neutrophil ratios in patients with mechanical thrombectomy for acute ischemic stroke. J Cerebrovasc Endovasc Neurosurg. 2022 Apr 21. doi: 10.7461/jcen.2022.E2021.10.003. Epub ahead of print. PMID: 35443275.)).
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