Show pageBacklinksCite current pageExport to PDFBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. Zhang et al., found that [[TRIM8]] activates [[STAT3]] by suppressing the expression of [[PIAS3]], an inhibitor of STAT3, most likely through E3-mediatiated ubiquitination and proteasomal degradation. Interestingly, they also found that STAT3 activation upregulates TRIM8, providing a mechanism for normalized TRIM8 expression in the setting of hemizygous gene deletion. These data demonstrate that bidirectional TRIM8-STAT3 signaling regulates stemness in GSC ((Zhang C, Mukherjee S, Tucker-Burden C, Ross JL, Chau MJ, Kong J, Brat DJ. TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3. Mol Oncol. 2017 Jan 18. doi: 10.1002/1878-0261.12034. [Epub ahead of print] PubMed PMID: 28100038. )). pias3.txt Last modified: 2024/06/07 02:49by 127.0.0.1