Phagosome [Neurosurgery Wiki]

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===== Phagosome =====

A **phagosome** is a [[membrane]]-bound [[vesicle]] formed around a [[particle]] engulfed by a phagocytic cell through the process of [[phagocytosis]]. Once internalized, the phagosome fuses with **[[lysosome]]s** to form a **phagolysosome**, where the contents are degraded by [[enzyme]]s.

Phagosomes play a crucial [[role]] in the **innate immune response**, particularly in the clearance of [[pathogen]]s and apoptotic cells. In the context of [[glioblastoma|glioblastoma (GB)]], changes in **phagosome-related protein expression** may reflect alterations in **immune surveillance**, **tumour-associated macrophage activity**, and **neuroinflammatory mechanisms**.

Recent studies, such as those by Liu et al. have linked **phagosome pathways** to potential **biomarker candidates** in GB, suggesting a role in disease progression and tumour-host interactions
((Liu X, Abmanhal-Masarweh H, Iwanowytsch O, Okwelogu E, Arashvand K, Karabatsou K, Ivo D'Urso P, Roncaroli F, Kostarelos K, Kisby T, Hadjidemetriou M. Plasma-to-tumour tissue integrated proteomics using nano-omics for biomarker discovery in glioblastoma. Nat Commun. 2025 Apr 10;16(1):3412. doi: 10.1038/s41467-025-58252-0. PMID: 40210624.))