Show pageBacklinksCite current pageExport to PDFBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. A key mode of [[transcriptional regulation]] by [[HOX]] and [[PBX]] proteins is through their interaction as a heterodimer or larger complex that enhances their binding affinity and specificity for DNA, and there is growing evidence that this interaction is a potential therapeutic target in malignancies that include prostate, breast, renal, ovarian and lung cancer, melanoma, myeloma, and acute myeloid leukemia ((Morgan R, El-Tanani M, Hunter KD, Harrington KJ, Pandha HS. Targeting HOX/PBX dimers in cancer. Oncotarget. 2017 May 9;8(19):32322-32331. doi: 10.18632/oncotarget.15971. PMID: 28423659; PMCID: PMC5458287.)) pbx.txt Last modified: 2024/06/07 02:50by 127.0.0.1