partial_response [Neurosurgery Wiki]

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Partial Response (PR): Requires all of the following:

≥50% decrease in sum of products of perpendicular diameters or ≥65% decrease in total volume [54, 70, 96] of all measurable enhancing lesions compared with baseline, sustained for at least 4 weeks. The first scan exhibiting ≥50% decrease in sum of products of perpendicular diameters or ≥65% decrease in total volume [54, 70, 96] of all measurable enhancing lesions compared with baseline is considered “preliminary PR”. If the second scan exhibits PD with respect to the “preliminary PR” scan, then the response is not sustained, noted as pseudoresponse, PsR, and is now considered “preliminary PD” (note confirmed PD requires at least two sequential increases in tumor volume). If the second scan exhibits SD, PR, or CR, it is considered a durable PR and the patient should continue on therapy until confirmed PD is observed.
Steroid dose should be the same or lower compared with baseline scan.
Stable or improved clinical assessments.
Note: Patients with non-measurable disease only at baseline cannot have PR; the best response possible is stable disease (SD).

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