Oxycodone [Neurosurgery Wiki]

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====== Oxycodone ======

Controlled-release oxycodone is an effective [[analgesic]] for the management of steady pain, paroxysmal spontaneous pain, and [[allodynia]], which frequently characterize [[postherpetic neuralgia]].
((Watson CPN, Babul N. Efficacy of [[oxycodone]] in [[neuropathic pain]]: a [[randomized trial]] in [[postherpetic neuralgia]]. Neurology. 1998; 50:1837–1841)).
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Supplied: usually available in combination as:

[[aspirin]] 325 mg with oxycodone 5 mg (Percodan®)
or [[acetaminophen]] (APAP) (Tylox® = APAP 500 mg + oxycodone 5 mg)

(Percocet® = oxycodone/APAP in 2.5/325, 5/325, 7.5/500, 10/650)

dose: 1 PO q 3–4 hrs PRN (may increase up to 2 PO q 3 hrsa)

Supplied: also available alone as OxyIR® 5 mg, OxyFast® oral solution of 20 mg/ml, or in controlled-release tablets as OxyContin® 10, 20, 40, 80b & 160b mg (which last 12 hours, achieving steady state in 24–36 hours).

℞ Adult: OxyContin® tablets are taken whole and are not to be divided, chewed, or crushed. It is intended for the management of moderate to severe pain when a continuous around-the-clock analgesic is needed for an extended period of time and is not intended for use as a PRN analgesic. For opiate naive patients, start with 10 mg PO q 12 hrs. For patients on narcotic medications, a conversion table is provided below for some medications. Titrate dose every 1–2 days, increasing dose by 25–50% q 12 hrs.