Orbital meningioma [Neurosurgery Wiki]

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====== Orbital meningioma ======

[[Meningioma]]s of the [[orbit]] are uncommon. 

====Classification====

They can be divided into two broad categories:

[[Primary orbital meningioma]]

[[Secondary orbital meningioma]]


[[Orbital meningioma]]s can be classified as primary [[optic nerve sheath meningioma]]s, primary intraorbital ectopic (Ob) meningiomas and [[sphenoorbital meningioma]]s (Sph-Ob) based on anatomic site. 

There are genomic alterations in 68% (13 of 19) of orbital meningiomas. Sph-Ob tumors frequently exhibited monosomy 22/22q loss (70%; 7/10) and deletion of chromosome 1p, 6q and 19p (50% each; 5/10). Among genetic alterations, loss of chromosome 1p and 6q were more frequent in clinically progressive tumors. Chromosome 22q loss also was detected in the majority of Ob meningiomas (75%; 3/4) but was infrequent in ON meningiomas (20%; 1/5). In general, Ob tumors had fewer chromosome alterations than Sph-Ob and ON tumors. Unlike Sph-Ob meningiomas, most of the Ob and ON meningiomas did not progress even after incomplete excision, although follow-up was limited in some cases. A study suggests that ON, Ob and Sph-Ob meningiomas are three molecularly distinct entities. The results also suggest that molecular subclassification may have prognostic implications
((Ho CY, Mosier S, Safneck J, Salomao DR, Miller NR, Eberhart CG, Gocke CD,
Batista DA, Rodriguez FJ. Genetic profiling by single-nucleotide
polymorphism-based array analysis defines three distinct subtypes of orbital
meningioma. Brain Pathol. 2015 Mar;25(2):193-201. doi: 10.1111/bpa.12150. Epub
2014 May 21. PubMed PMID: 24773246; PubMed Central PMCID: PMC4324373.
)).