Oncoprotein [Neurosurgery Wiki]

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====== Oncoprotein ======

Oncoproteins are any [[protein]]s coded by an [[oncogene]] and they play an important role in the regulation or synthesis of proteins linked to tumorigenic cell growth. Some oncoproteins are accepted and used as [[tumor marker]]s.
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Limitations in [[genetic stability]] and recapitulating accurate physiological disease properties challenge the utility of patient-derived (PD) [[cancer models]] for reproducible and [[translational research]].

Uhlmann et al. from the [[University Hospital of Düsseldorf]], genetically engineered a [[portfolio]] of [[isogenic]] [[human-induced pluripotent stem cell]]s (hiPSCs) with different pan-[[cancer]] relevant [[oncoprotein]] [[signature]]s followed by differentiation into lineage-committed [[progenitor cell]]s. Characterization on molecular and biological level validated successful stable [[genetic alterations]] in [[pluripotency]] state as well as upon differentiation to prove the functionality of the approach Meanwhile proposing core molecular networks possibly involved in early dysregulation of [[stem cell]] [[homeostasis]], the application of the cell systems in comparative substance testing indicates the potential for [[cancer]] [[research]] such as identification of augmented [[therapy]] resistance of [[stem cell]]s in response to activation of distinct oncogenic [[signature]]s
((Uhlmann C, Nickel AC, Picard D, Rossi A, Li G, Hildebrandt B, Brockerhoff G, Bendt F, Hübenthal U, Hewera M, Steiger HJ, Wieczorek D, Perrakis A, Zhang W, Remke M, Koch K, Tigges J, Croner RS, Fritsche E, Kahlert UD. [[Progenitor cell]]s derived from [[gene]]-engineered human induced [[pluripotent stem cell]]s as synthetic cancer cell alternatives for [[in vitro]] pharmacology. Biotechnol J. 2022 Mar 25:e2100693. doi: 10.1002/biot.202100693. Epub ahead of print. PMID: 35334498.)).
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F-box and WD repeat domain-containing 7([[FBW7]]) is a SCF-type E3 [[ubiquitin]] ligase targeting a multitude of [[oncoprotein]]s for degradation.