Show pageBacklinksCite current pageExport to PDFBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. ====== Objective response rate ====== When used as a clinical endpoint for clinical trials of cancer treatments, this often called the objective [[response rate]] (ORR). The FDA definition of ORR is "the proportion of patients with tumor size reduction of a predefined amount and for a minimum time period." However, [[PFS]] and ORR also have challenges, as determination of response and [[progression]] using anatomic imaging techniques may suffer from issues associated with measurement variability and discordance in interpretation between radiologists ((Provenzale JM, Ison C, Delong D. Bidimensional measurements in brain tumors: assessment of interobserver variability. AJR Am J Roentgenol. 2009 Dec;193(6):W515-22. doi: 10.2214/AJR.09.2615. PubMed PMID: 19933626. )) objective_response_rate.txt Last modified: 2024/06/07 02:54by 127.0.0.1