Show pageBacklinksCite current pageExport to PDFFold/unfold allBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. ====== Objective response rate ====== When used as a clinical endpoint for clinical trials of cancer treatments, this often called the objective [[response rate]] (ORR). The FDA definition of ORR is "the proportion of patients with tumor size reduction of a predefined amount and for a minimum time period." However, [[PFS]] and ORR also have challenges, as determination of response and [[progression]] using anatomic imaging techniques may suffer from issues associated with measurement variability and discordance in interpretation between radiologists ((Provenzale JM, Ison C, Delong D. Bidimensional measurements in brain tumors: assessment of interobserver variability. AJR Am J Roentgenol. 2009 Dec;193(6):W515-22. doi: 10.2214/AJR.09.2615. PubMed PMID: 19933626. )) objective_response_rate.txt Last modified: 2025/04/29 20:25by 127.0.0.1