Show pageBacklinksCite current pageExport to PDFBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. ====== Noncomparative study ====== Unblinded (open) study without control group; although lack of controls will most often lead to the problem of confounding by the indication, comparative studies are not always necessary/ethically justified to evaluate drug efficacy esp. in the following examples: (1) drug effect is very dramatic (e.g. prompt awakening of a patient who is comatose from an overdose of methadone when naloxone is administered), (2) predictable, invariable, progressive disease without therapy (e.g. scurvy, if vitamin C is not administered), (3) disease without spontaneous cure (e.g. gonorrhea, treatment with suitable antibiotic); noncomparative_study.txt Last modified: 2024/06/07 02:55by 127.0.0.1