Show pageBacklinksCite current pageExport to PDFBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. ====== Nitroglycerin ====== Nitroglycerin (also known as glyceryl trinitrate (GTN)), a vasodilator best known for treatment of ischemic heart disease, has also been investigated for its potential therapeutic benefit in [[ischemic stroke]]. Raises [[ICP]] (less than with [[nitroprusside]] due to preferential venous action) ((Cottrell JE, Patel K, Turndorf H, Ransohoff J. Intracranial pressure changes induced by sodium nitroprusside in patients with intracranial mass lesions. J Neurosurg. 1978 Mar;48(3):329-31. PubMed PMID: 632856. )). This agent produces a rapid, controllable, but not precipitous fall in blood pressure without rebound, is non-toxic, may not alter cerebrovascular autoregulation, and does not raise intracranial pressure ((Chestnut JS, Albin MS, Gonzalez-Abola E, Newfield P, Maroon JC. Clinical evaluation of intravenous nitroglycerin for neurosurgery. J Neurosurg. 1978 May;48(5):704-11. PubMed PMID: 417150. )). ===== Dosage ===== 5 mcg/min Increase by 5 mcg/min q3-5min up to 20 mcg/min, THEN Increase by 10 mcg/min May later increase by 20 mcg/min Higher dosages required for PVC admin sets Uninterrupted infusion >24 hours produces tolerance nitroglycerin.txt Last modified: 2024/06/07 02:58by 127.0.0.1