Nimodipine for Cerebral Vasospasm Prevention [Neurosurgery Wiki]

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====== Nimodipine for Cerebral Vasospasm Prevention ======



Nimodipine is the only approved prophylactic medication. In addition to its anticoagulant properties, [[heparin]] also has a pleiotropic and anti-inflammatory effect that could be beneficial in vasospasm. 

Administration of intravenous UFH for more than 48 hours reduced the rate of cerebral infarction with a good safety profile. This result supports the ongoing clinical trial
((Lukito PP, Lie H, Helsa K, July J. Heparin in the treatment of aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. Neurosurg Focus. 2022 Mar;52(3):E9. doi: 10.3171/2021.12.FOCUS21419. PMID: 35231899.)).
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Removal of [[subarachnoid hemorrhage]] as soon as possible.

Installation of [[thrombolytic agent]]s (e.g. urokinase).

Antiinflammatory agents (steroids or NSAIDs).

===== Nimodipine for subarachnoid hemorrhage =====


see [[Nimodipine for aneurysmal subarachnoid hemorrhage]].

see [[Nimodipine for traumatic subarachnoid hemorrhage]].