Neurotoxicity [Neurosurgery Wiki]

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=====Neurotoxicity=====
Neurotoxicity occurs when exposure to natural or artificial toxic substances, which are called [[neurotoxin]]s, alters the normal activity of the [[nervous system]] in such a way as to cause damage to nervous tissue. This can eventually disrupt or even kill [[neuron]]s, key cells that transmit and process signals in the brain and other parts of the nervous system. 

Neurotoxicity can result from exposure to substances used in [[chemotherapy]], radiation treatment, drug therapies, certain drug abuse, and organ transplants, as well as exposure to heavy metals, certain foods and food additives, pesticides, industrial and/or cleaning solvents, cosmetics, and some naturally occurring substances. 

Symptoms may appear immediately after exposure or be delayed.

see [[Neurotoxicity syndrome]]
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Studies mainly in [[animal]] (rodent and porcine) ICH models have shown the role of bound and unbound [[iron]] in causing [[neurotoxicity]] following an ICH.