National Center for Global Health and Medicine [Neurosurgery Wiki]

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====== National Center for Global Health and Medicine ======

{{rss>https://pubmed.ncbi.nlm.nih.gov/rss/search/14ipX3fGPZTCtItO16cGJ9mjpkAMvbPcZb9VM1formO2fEPkoT/?limit=15&utm_campaign=pubmed-2&fc=20250327122831}}

https://www.hosp.ncgm.go.jp/en/index.html
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National Center for Global Health and Medicine in [[Tokyo]]
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Tetsuo Hara 
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Atsushi Fukui 
===== Retrospective observational studies =====
Sakurai et al. conducted a [[retrospective]] [[observational study]] on patients with [[COVID-19]] admitted to the [[National Center for Global Health and Medicine]] who subsequently died during the [[delta]] (July-September 2021) and [[omicron]] variant outbreaks (December 2021-August 2022). Among the 20 patients who died during the delta variant epidemic, the main causes of death were [[pneumonia]] (n = 16, 80%), preadmission complications (n = 3, 15%), and complications occurring during [[hospitalization]] (n = 1, 5%). However, during the omicron variant epidemic, 7/24 patients (29%) died of pneumonia, 11 (46%) died of complications before [[admission]], and 6 (25%) died of complications during admission. During the omicron variant outbreak, two-thirds of the COVID-19 deaths during hospitalization were not primarily caused by pneumonia, unlike the delta variant outbreak, during which pneumonia had a greater impact on mortality. As patient demographics and clinical pictures change, the establishment of medical infrastructure for patients with life-threatening comorbidities and careful monitoring of acute [[COVID]]-related complications are essential
((Sakurai A, Morioka S, Tsuzuki S, Matsunaga N, Saito S, Arai N, Yamamoto N, Hara T, Hojo M, Hiroi Y, Yamada K, Ohmagari N. Difference in clinical courses and causes of COVID-19-related deaths in hospitalized patients infected with omicron and delta variants: A retrospective study in Japan. GHM Open. 2024 Jul 31;4(1):23-31. doi: 10.35772/ghmo.2023.01025. PMID: 40144739; PMCID: PMC11933933.))
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Sakurai et al.'s study contributes important preliminary [[observation]]s about the evolving nature of COVID-19 mortality. However, its limited sample size, single-center design, and lack of detailed covariate adjustment restrict the strength of its conclusions. The key takeaway—that pneumonia is no longer the dominant cause of COVID-related death in the Omicron era—serves as a vital reminder for clinicians and [[policymaker]]s to adapt strategies to the changing clinical [[landscape]] of the [[pandemic]].