NADH [Neurosurgery Wiki]

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====== NADH ======
 

[[NADH]] stands for "[[nicotinamide adenine dinucleotide]] (NAD) + hydrogen (H)." It occurs naturally in the body and plays a role in generating energy. The NADH produced by the body is involved in making energy in the body. Taking NADH supplements might affect blood pressure and have other effects.
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Mutations in [[isocitrate dehydrogenase]] ([[IDH]]) 1 & 2 genes reduce the enzymatic capacity of their coded [[protein]]s to bind their [[substrate]], [[isocitrate]], and convert it into α-ketoglutarate (α-KG), generating [[carbon dioxide]] and replenishing [[NADH]] and [[NADPH]] as side products
((Yen KE, Bittinger MA, Su SM, Fantin VR. Cancer-associated IDH mutations: biomarker and therapeutic opportunities. Oncogene. 2010 Dec 9;29(49):6409-17. doi: 10.1038/onc.2010.444. Epub 2010 Oct 25. PMID: 20972461.))