Myeloproliferative Neoplasm stem cells [Neurosurgery Wiki]

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====== Myeloproliferative Neoplasm stem cells ======

Myeloproliferative [[neoplasm]]s (MPNs) are clonal disorders of [[hematopoietic stem cell]]s, which are the cells responsible for producing all types of [[blood cell]]s. In MPNs, there is an abnormal proliferation of these stem cells, leading to the overproduction of blood cells.

Recent research suggests that the underlying cause of MPNs may be genetic mutations in the [[hematopoietic stem cell]]s themselves. For example, a specific mutation in the [[JAK2]] gene (JAK2 V617F) has been found in a significant proportion of patients with MPNs, and is thought to play a key role in the development of these diseases.

The abnormal stem cells in MPNs have been shown to have an increased ability to self-renew and differentiate into various blood cell lineages, leading to the overproduction of mature blood cells. In addition, these abnormal stem cells may have altered signaling pathways and interactions with the bone marrow microenvironment, which can contribute to the progression and severity of the disease.

Current therapies for MPNs are aimed at reducing the production of blood cells and managing symptoms but do not typically target the underlying abnormal stem cells. However, research into new therapies that target abnormal stem cells is ongoing, with the goal of developing more effective and curative treatments for MPNs.