MST1 [Neurosurgery Wiki]

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=====MST1=====
[[Macrophage stimulating protein]] (MSP), also known as [[hepatocyte growth factor like protein]] (HLP, HGFL, or HGFLP), is a protein that in humans is encoded by the MST1 (macrophage-stimulating 1) gene.

Guo et al. showed that [[Transforming growth factor Beta]] induced the downregulation of [[MST1]] expression in U87 and U251 glioma cells. Treatment of glioma cells with the DNA methylation inhibitor [[Decitabine]] (5-aza-2'-deoxycytidine 5-AzadC) prevented the loss of MST1 expression. Addition of 5-AzadC also reduced the TGF-β-stimulated proliferation, migration and invasiveness of glioma cells. Furthermore, Knockdown of [[DNMT1]] upregulated MST1 expression in gliomas cells. In addition, the inhibition of DNMT1 blocked TGF-β-induced proliferation, migration and invasiveness in glioma cells. These results suggest that TGF-β promotes glioma malignancy through DNMT1-mediated loss of MST1 expression
((Guo Z, Li G, Bian E, Ma CC, Wan J, Zhao B. TGF-β-mediated repression of MST1
by DNMT1 promotes glioma malignancy. Biomed Pharmacother. 2017 Aug 9;94:774-780. 
doi: 10.1016/j.biopha.2017.07.081. [Epub ahead of print] PubMed PMID: 28802229.
)).