Show pageBacklinksCite current pageExport to PDFBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. =====Monoamine oxidase B===== [[Monoamine oxidase]] B (MAOB) is highly expressed in [[glioblastoma]] cell mitochondria, and mitochondrial function is intimately tied to treatment-resistant glioblastoma progression. These glioblastoma properties provide a strong rationale for pursuing a MAOB-selective pro-drug treatment approach that, upon drug activation, targets glioblastoma mitochondria, especially mitochondrial DNA. MP-MUS is the lead compound in a family of pro-drugs designed to treat GBM that is converted into the mature, mitochondria-targeting drug, P(+)-MUS, by MAOB. Sharpe et al., show that MP-MUS can successfully kill primary gliomas in vitro and in vivo mouse xenograft models. monoamine_oxidase_b.txt Last modified: 2024/06/07 02:50by 127.0.0.1