Molecular profiling [Neurosurgery Wiki]

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====== Molecular profiling ======

The [[comprehensive]] [[molecular]] [[profiling]] of cancer has resulted in new insights into the biology and [[classification]] of numerous [[tumor]] types.

The classification of [[tissue]] or other specimens for diagnostic, prognostic, and predictive purposes based on multiple [[gene expression]], is a technology that holds major promise for optimizing the management of patients with cancer.

Molecular profiling refers to the study of specific patterns, or signature, of the following:

Protein ([[Proteomics]]; Oncopeptidomics)

[[mRNA]] ([[Gene Expression Profiling]]; Microarray (cDNA) Technology; RNA Profiling; OncoArray; Oncotype DX; MammaPrint)

DNA (Polymorphism; Metabolic Polymorphisms; Metabolic Polymorphisms and Cancer Susceptibility)

Epigenetic status (Epigenome).
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see [[Single-cell transcriptome profiling]].
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[[Molecular profiling]] of GBM has become crucial for improving diagnosis, predicting prognosis, and guiding personalized therapies. [[Next-generation sequencing]] (NGS) has emerged as a powerful tool to comprehensively analyze the genetic [[landscape]] of GBM, providing insights into its heterogeneity and potential therapeutic targets.