mir_539 [Neurosurgery Wiki]

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The deepgoing role of [[Long non-coding RNA]] (lncRNAs) on [[meningioma]] is still unclear. 

Xing et al., investigated the roles of lncRNA [[LINC00460]] in meningioma tissue and uncover its molecular mechanism. Results revealed that LINC00460 expression level was significantly up-regulated in meningioma tissues and malignant meningioma cell lines (IOMM-Lee, CH157-MN). Mechanically, loss-of-function assays showed that LINC00460 knockdown significantly suppressed the proliferation ability, increased the apoptosis and decreased the proteins (MMP-2, MMP-9, ZEB1) expression. Bioinformatics tools predicted that [[miR 539]] both targeted with the 3'-UTR of LINC00460 and MMP-9 mRNA, which was confirmed by luciferase reporter assay and western blot analysis. In summary, our study reveals that LINC00460 promotes MMP-9 expression through targeting miR-539, acting as an oncogenic RNA in the meningeoma malignancy and accelerating the proliferation and metastasis of meningeoma
((Xing H, Wang S, Li Q, Ma Y, Sun P. Long non-coding RNA LINC00460 targets
miR-539/MMP-9 to promote meningioma progression and metastasis. Biomed
Pharmacother. 2018 Jun 12;105:677-682. doi: 10.1016/j.biopha.2018.06.005. [Epub
ahead of print] PubMed PMID: 29906745.
)).