mir_498 [Neurosurgery Wiki]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.

Jin et al., found that [[Long noncoding RNA]] [[CASC11]] was significantly up-regulated in the [[glioma]] specimens and cells, and the ectopic overexpression indicated the poor prognosis of glioma patients. CASC11 expression could be activated by the [[SP1 transcription factor]]. In vivo and vitro, the [[knockdown]] of CASC11 impaired the proliferation, migration and tumor growth of glioma cells. In mechanical experiments, the [[miR 498]] was found to target the 3'-UTR of lncRNA CASC11 and [[FOXK1]] mRNA. Taken together, the data suggest the regulation of SP1/CASC11/miR-498/FOXK1 in the gliomagenesis, which might provide a potential therapeutic strategy for glioma
((Jin J, Zhang S, Hu Y, Zhang Y, Guo C, Feng F. SP1 induced lncRNA CASC11
accelerates the glioma tumorigenesis through targeting FOXK1 via sponging
miR-498. Biomed Pharmacother. 2019 May 20;116:108968. doi:
10.1016/j.biopha.2019.108968. [Epub ahead of print] PubMed PMID: 31121483.
)).