miR 206 [Neurosurgery Wiki]

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====== miR 206 ======

Early [[brain injury]] (EBI) is the most important potentially treatable cause of [[mortality]] and [[morbidity]] following [[subarachnoid hemorrhage]] (SAH). [[Apoptosis]] is one of the main pathologies of [[SAH]]-induced EBI. Numerous studies suggest that human [[umbilical cord]] derived [[mesenchymal stem cell]]s (hucMSCs) may exert a neuroprotective effect through [[exosome]]s instead of [[transdifferentiation]]. In addition, [[microRNA]]-206 (miR-206) targets [[BDNF]] and plays a critical role in brain injury diseases. However, the therapeutic effect of miR-206 modified exosomes on EBI after SAH and its regulatory mechanism have not been elucidated. To identify whether hucMSCs-derived miR-206-knockdown exosomes have a better neuroprotective effect, Zhao et al. established SAH [[rat]] model and treated with the [[exosome]]s to [[research]] the mechanism of miR-206 in EBI after SAH. They found that treatment with hucMSCs-derived miR-206-knockdown exosomes has a greater neuroprotective effect on SAH-induced EBI compared to treatment with simple exosomes. The miR-206-knockdown exosomes could significantly improve [[neurological deficit]], [[brain edema]] and suppress neuronal [[apoptosis]] by targeting BDNF. Moreover, the BDNF/TrkB/CREB pathway was activated following treatment with miR-206 modified exosomes in vivo. In summary, these findings indicate that the hucMSCs-derived miR-206-knockdown exosomes prevent early brain injury by inhibiting apoptosis via BDNF/TrkB/CREB signaling. This may serve as a novel therapeutic target for the treatment of SAH-induced EBI
((Zhao H, Li Y, Chen L, Shen C, Xiao Z, Xu R, Wang J, Luo Y. HucMSCs-Derived
miR-206-Knockdown Exosomes Contribute to Neuroprotection in Subarachnoid
Hemorrhage Induced Early Brain Injury by Targeting BDNF. Neuroscience. 2019 Aug
7. pii: S0306-4522(19)30542-1. doi: 10.1016/j.neuroscience.2019.07.051. [Epub
ahead of print] PubMed PMID: 31400488.
)).