mir_152 [Neurosurgery Wiki]

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A study investigated the activity of [[FBXL7]] and miR-152-5p in glioma. Levels of microRNA-152-5p (miR-152-5p) and the transcript and protein of FBXL7 were assessed by real-time PCR and Western blotting, respectively. The migratory and invasive properties of cells were measured by Transwell migration and invasion assay and their viability were examined using CCK-8 assay. Further, the putative interaction between FBXL7 and miR-152-5p were analysed bioinformatically and by luciferase assay. The activities of FBXL7, TMZ and miR-152-5p were analysed in vivo singly or in combination, on mouse xenografts, in glioma tumorigenesis. The expression of FBXL7 in glioma tissue is significantly up-regulated, which is related to the poor prognosis and the grade of glioma. TMZ-induced cytotoxicity, proliferation, migration and invasion in glioma cells were impeded by the knock-down of FBXL7 or overexpressed miR-152-5p. Furthermore, the expression of miR-152-5p reduced remarkably in glioma cells and it exerted its activity through targeted FBXL7. Overexpression of miR-152-5p and knock-down of FBXL7 in glioma xenograft models enhanced TMZ-mediated anti-tumour effect and impeded tumour growth. Thus, the miR-152-5p suppressed the progression of glioma and associated tumorigenesis, targeted FBXL7 and increased the effect of TMZ-induced cytotoxicity in glioma cells, further enhancing our knowledge of FBXL7 activity in glioma
((Kong S, Fang Y, Wang B, Cao Y, He R, Zhao Z. miR-152-5p suppresses glioma
progression and tumorigenesis and potentiates temozolomide sensitivity by
targeting FBXL7. J Cell Mol Med. 2020 Mar 9. doi: 10.1111/jcmm.15114. [Epub ahead
of print] PubMed PMID: 32150671.
)).
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MiR-152 regulated cell proliferation and apoptosis of glioma mediated by Runx2, while the mechanism of down regulated miR-152 in glioma tissues and cells was its hypermethylation
((Zhang P, Sun H, Yang B, Luo W, Liu Z, Wang J, Zuo Y. miR-152 regulated glioma 
cell proliferation and apoptosis via Runx2 mediated by DNMT1. Biomed
Pharmacother. 2017 Jun 5;92:690-695. doi: 10.1016/j.biopha.2017.05.096. [Epub
ahead of print] PubMed PMID: 28595085.
)).
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miR-152-3p can inhibit glioma cell proliferation and invasion activities by decreasing [[DNMT1]]. The restoration of miR-152-3p may have therapeutic application in the treatment of [[GBM]]
((Sun J, Tian X, Zhang J, Huang Y, Lin X, Chen L, Zhang S. Regulation of human
glioma cell apoptosis and invasion by miR-152-3p through targeting DNMT1 and
regulating NF2 : MiR-152-3p regulate glioma cell apoptosis and invasion. J Exp
Clin Cancer Res. 2017 Aug 1;36(1):100. doi: 10.1186/s13046-017-0567-4. PubMed
PMID: 28764788.
)).