mir 137 [Neurosurgery Wiki]

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====== mir 137 ======

Data suggest that [[WIF1]] may be potential [[biomarker]] for the aggressiveness of NFPAs. [[mir 137]] plays an important role in the [[Wnt signaling pathway]] by affecting promoter methylation of [[WIF1]]
((Song W, Qian L, Jing G, Jie F, Xiaosong S, Chunhui L, Yangfang L, Guilin L,
Gao H, Yazhuo Z. Aberrant expression of the sFRP and WIF1 genes in invasive
non-functioning pituitary adenomas. Mol Cell Endocrinol. 2018 Oct 15;474:168-175.
doi: 10.1016/j.mce.2018.03.005. Epub 2018 Mar 16. PubMed PMID: 29555596.
)).

miR 137 and [[miR 195]] act as vasculogenic suppressors in AVMs by altering phenotypic properties of AVMSMCs, and that the absence of miR-137 and miR-195 expression leads to abnormal vasculogenesis
((Huang J, Song J, Qu M, Wang Y, An Q, Song Y, Yan W, Wang B, Wang X, Zhang S,
Chen X, Zhao B, Liu P, Xu T, Zhang Z, Greenberg DA, Wang Y, Gao P, Zhu W, Yang
GY. MicroRNA-137 and -195* inhibit vasculogenesis in brain arteriovenous
malformations. Ann Neurol. 2017 Aug 12. doi: 10.1002/ana.25015. [Epub ahead of
print] PubMed PMID: 28802071.
)).