miR 105 [Neurosurgery Wiki]

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=====miR 105=====
[[MiR]]-105 was identified as a remarkably decreased [[MicroRNA]] in [[glioblastoma]] compared with [[WHO grade 3 glioma]]s (P=0.012, fold change =0.04). 

Guan et al. subsequently examined its expression levels in an independent series of [[glioma]]s, and statistically analyzed the associations between miR-105 expression and clinicopathological characteristics and survivals of these glioma patients. MiR-105 showed remarkably decreased expression in gliomas as compared to non-neoplastic brains. And [[grade 4 glioma]]s had significantly lower miR-105 expression compared with grade III and [[WHO grade 2 glioma]]s (both P<0.001). Additionally, low miR-105 expression was statistically associated with advanced tumor grade, advanced patient's age and low pre-operative Karnofsky performance score (all P<0.001). Furthermore, patients with low miR-105 expression had significantly poorer survival by Kaplan-Meier method (P<0.001). Multivariate analysis indicated miR-105 as an independent prognostic indicator for glioma patients (P=0.018, risk ratio =4.2).

The results suggested that low expression of miR-105 may correlate with unfavorable clinical outcome and be involved in [[tumorigenesis]] and aggressive progression of glioma. And miR-105 may be a novel [[biomarker]] in prognostic prediction for glioma
((Guan Y, Chen L, Bao Y, Li Z, Cui R, Li G, Wang Y. Identification of low
miR-105 expression as a novel poor prognostic predictor for human glioma. Int J
Clin Exp Med. 2015 Jul 15;8(7):10855-10864. eCollection 2015. PubMed PMID:
26379879.
))